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In summary, Octaplasma is a pooled, solvent/detergent-treated, plasma product derived from the pooled plasma of at least 1,000 donors. It is a sterile, apyrogenic, frozen solution of human plasma proteins, which contains labile coagulation factors in concentrations that approximate those in fresh frozen plasma. Octaplasma is used for replacement therapy in patients with congenital or acquired deficiencies of coagulation factors, and in patients undergoing plasma exchange. The manufacturing process for Octaplasma involves several steps, including donor selection, plasma collection, plasma preparation, solvent/detergent treatment, filtration, and final product testing. Octaplasma is a safe and effective plasma product, and it has been used in clinical practice for over 20 years.